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photo management rheumatology differential activation algorithm antimda5 antimda5dm antinxp2 antinxp2dm bandemia canimorsus capnocytophaga cbc classification cutaneous erythematosus eschar gottrons gottronspapules
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... dorsal part of the MCP ... auricular papules Clinical ... dermatology #diagnosis
Dermatomyositis with heliotrope rash, shawl sign, and Gottron's papules A middle-aged man describes progressive difficulty combing his
with heliotrope rash ... 1) heliotrope rash ... #heliotrope #skinrash ... GottronsPapules #dermatology ... #clinical #photo
Gottron's Papules in Dermatomyositis Another classic clue is Gottron's papules which are small grouped flat topped papules
Gottron's Papules in Dermatomyositis ... surfaces of joints (MCP ... Gottrons #Papules #Rash ... #Dermatomyositis ... #Dermatology #Clinical
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... with leukopenia, anemia ... 5000 to 10,000 ng/mL ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Differential Diagnosis ... likelihood of negative clinical ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
Canimorsus Skin Rash ... Bandemia, AKI. ... possible Patient's clinical ... the key to the diagnosis ... #dermatology #clinical
General Approach to Anemia - Differential Diagnosis Framework 1) Check reticulocyte count to determine if hypo/hyper-proliferative 2) Exclude
General Approach to Anemia ... - Differential Diagnosis ... haptoglobin) 3) Use MCV ... & clinical context ... #hematology #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Still disease, dermatomyositis ... lymphopenia, low PLT • Anemia ... La, anti-Jo-1, SCL
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... dorsal part of the MCP ... auricular papules Clinical ... dermatology
Cutaneous larva migrans skin Rash 25 F recent Caribbean vacation, walked barefoot on sand and now with
. diagnosis? ... self-limited Diagnosis ... is clinical & labs ... larva #migrans #skinRash ... #dermatology #clinical
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