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diagnosis rheumatology hodgkins leukemia syndrome allergy behcet chronic classification comparison dermatology disease erythematosus hemophagocytic hlh immunology lupus lymphocytic lymphohistiocytosis monoclonal
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... (SLL) CLL Symptoms ... -> Invade Skin: ... (SLL) • Sudden ... #Hematology #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Autoimmune diseases • Clinical ... • Other hematologic ... Malignancies (eg CML ... NonHodgkins #comparison #oncology ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
SLL CLL Epidemiology ... Orange or Hep C Clinical ... Hepatomegaly • Skin ... diagnosis #workup #oncology ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & ... Evans • ITP • Cl-NH ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... classical HL (MCHL ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... lymphoma, B-cell ... lymphoma (DLBCL ... Autoimmune diseases: SLE ... Lymphohistiocytosis #diagnosis #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behcet disease) Differential ... Oral aphthae : SLE ... Ischemia, Leukemia, Lymphoma ... • Arthritis: SLE ... Syndrome #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... permanent alopecia Differential ... Malignancy (e.g. hematologic ... lymphoma • Evans
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... • B cell lymphoma ... #Diagnosis #Management
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
myeloid leukemia (CML ... Non-Hodgkin's lymphoma ... positive if you see ... Pathergy #diagnosis #differential ... allergy #immunology #dermatology
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