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rheumatology differential lymphoma antinxp2 antinxp2dm associations cancers chronic classification comparison dermatology dermatomyositis erythematosus hemophagocytic hlh infection leukemia lupus lymphocytic lymphohistiocytosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Epidemiology: young adults ... • Other hematologic ... Malignancies (eg CML ... NonHodgkins #comparison #oncology ... #hematology
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
head and neck, skin ... cancer • HTLV-1 - Adult ... • EBV - NHL, Hodgkin's ... Associations #Cancers #oncology ... #differential #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... Hepatomegaly • Skin ... Diagnosis: • ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... classical HL (MCHL ... #lymphoma #diagnosis ... classification #hematology ... #oncology #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
sIL-2R >2400 Ul/ml ... Hemopathies+++: Hodgkin ... diseases: SLE+++, Adult-onset ... #management #treatment ... #summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... Malignancy (e.g. hematologic ... cyclophosphamide) • Hodgkin
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... Nephrogenic DI Hematologic ... Malignancy Risk: • Non-Hodgkins ... lubricants • Pharmacologic ... #Diagnosis #Management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... dorsal part of the MCP ... Dermatomyositis: • ILD was diagnosed ... Dermatomyositis #diagnosis ... #management #rheumatology
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