29 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... #Syndrome #MDS ... #treatment #hematology ... #oncology
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
associated with myelodysplastic ... most frequent skin ... #diagnosis #dermatology ... #oncology #clinical ... #skin
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... vasculitis • Hematologic ... multiple myeloma, myelodysplastic ... criteria for 1) hematologic ... Autoinflammatory #Somatic #rheumatology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic ... Syndromes (MDS) ... just beneath the skin ... Myelogenous Leukemia (CML ... #hematology #oncology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
) Low MCV - <80fL ... anemia" High MCV ... Hypothyroidism, Myelodysplastic ... syndrome - Dr ... diagnosis #causes #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Corpuscular Volume (MCV ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... Algorithm #Causes #Hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
/dL or CC < 40 ml ... M spike: • CML ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Headaches • Pale skin ... • Hypocellular myelodysplastic ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
(HCV) • CLL & MBL ... Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology