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diagnosis rheumatology disease medications treatment anemia antiil6 aplastic atopic behcet behcets covid19 dermatitis dermatology differential erythematosus leukemia lupus macrophage mds
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Syndrome (MAS) ... erythematosus [SLE ... 5000 to 10,000 ng/mL ... #Management #Hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... • Arthritis: SLE ... Reactive Arthritis, AS ... #diagnosis #management ... signs #symptoms #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... myopathy • Anti MAG ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19 IL-6 activates T cells and macrophages, among other cell types (see
other cell types (see ... “Cytokine Activation ... Syndrome” IL-6 ... Siltuximab #COVID19 #Pharmacology ... #Management #Medications
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... erythematosus (NPSLE): • May ... Seizures • Strokes Skin ... La, anti-Jo-1, SCL ... Chronic B-cell activation
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... refractory disease Skin ... #Treatment #management ... #pharmacology # ... rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL: mediastinal mass ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Atopic Dermatitis - Topical Treatment Options First Line: Topical Corticosteroids - High Potency: Betamethasone
After non-pharmacologic ... very different skin ... than roflumilast (see ... #Medications #Pharmacology ... #Dermatology #Management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(MDS) What? ... just beneath the skin ... Myelogenous Leukemia (CML ... #diagnosis #hematology ... #oncology
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