8 results
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... Procalcitonin <0.5 ng/mL ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics ... #Peds #Febrile
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... erythematosus • Kawasaki ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... following: • Fever ... Ferritin >500 ng/mL ... #management #treatment ... #hematology
The Febrile Infant Step-by-Step Algorithm
This is an algorithm developed by European emergency physicians to identify low-risk
empiric antibiotic treatment ... 92.0% and 46.9% #Diagnosis ... #EBM #Management ... #Pediatrics #Peds ... Stratification #Fever
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Risk ... • Dyspnea • Fever ... classical HL (MCHL ... Hodgkin Lymphoma Treatment ... #oncology #management
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
PV, MDS, CML) Treatment ... • Treatment algorithms ... appropriate only for low risk ... patients with no CV risk ... #diagnosis #management
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
respiratory symptoms • Fever ... pulmonary symptoms • Rheumatologic ... MUCORMYCOSIS • Risk ... Encapsulated yeast • At risk ... #Management #Infections