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management disease hematology pediatrics hemophagocytic hlh lymphohistiocytosis risk stepbystep stratification activation adult adultonset antibiotics aosd comparison cryptogenic erythematosus evaluation febrile
Step by Step Algorithmic Approach to Pediatric Fever Age < 21 days old (or 28 days for
Procalcitonin >= 0.5 ng/mL ... CRP mg/L or ANC ... #Pediatrics #Peds ... #Diagnosis #Management ... #Infant #Fever
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... Procalcitonin <0.5 ng/mL ... <10,000/mm3 - CRP ... < 20 mg/L #Diagnosis ... Management #Pediatrics #Peds
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Disease Clinical ... triad: Fever, Arthralgia ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Labs: • ↑ESR/CRP ... Ferritin >3000 ng/mL ... Treatment - Mild ... #rheumatology #
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Infants ≤6 months ... old on day ≥7 of fever ... echo is positive, treatment ... and lab signs (CRP ... #Diagnosis #Peds
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... : 33% • Treatment ... elevated BNP, high CVP ... , and CXR with pulmonary ... #diagnosis #comparison
Cryptogenic Organizing Pneumonia - Illness Script PATHOPHYSIOLOGY: Unknown trigger, reversible inflammatory/fibroproliferative process. Polypoid fibroblastic aggregates that plug
Cough, dyspnea, fever ... : Clinical diagnosis ... identified (autoimmune, meds ... , neoplastic) TREATMENT ... #management #pulmonary
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... +, Adult-onset Still ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... frequently affects infants ... following: • Fever ... Ferritin >500 ng/mL ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... is the main clinical ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Rheumatology
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