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management hematology pediatrics antibiotics febrile hemophagocytic lymphohistiocytosis risk stepbystep stratification activation brain classification crypto cryptococcal disease ebm fungal hodgkins incomplete
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... Procalcitonin <0.5 ng/mL ... CRP < 20 mg/L #Diagnosis ... Management #Pediatrics #Peds ... #LP #Antibiotics
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... frequently affects infants ... following: • Fever ... Ferritin >500 ng/mL ... #hematology
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
empiric antibiotic treatment ... 92.0% and 46.9% #Diagnosis ... Management #Pediatrics #Peds ... #LP #Antibiotics ... Stratification #Fever
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... is the main clinical ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Rheumatology
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Infants ≤6 months ... old on day ≥7 of fever ... if they have no clinical ... echo is positive, treatment ... #Diagnosis #Peds
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... • Dyspnea • Fever ... (MCHL) - Lymphocyte ... lymph node biopsy (diagnostic ... Hodgkin Lymphoma Treatment
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... symptoms • Rheumatologic ... has five major clinical ... fungal stain of clinical ... • Isolated fever
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
Diagnosis? ... of prior silent pulmonary ... Standard treatment ... If a second LP is ... T2 #MRI #Brain #clinical
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