11 results
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... Hepatitis • HIV Autoimmune ... • Rheumatoid Arthritis ... Pulmonary Disease Neurologic
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... • Chronic lung ... than 100 to 300 mg ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... disease • Non-autoimmune ... deficiencies • Autoimmune ... vein thrombosis Hematologic
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... spinal cord - Autoimmune ... patients with a long ... syndromes #lesions #differential ... #diagnosis #neurology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... Diagnosis = clinical ... very remarkable w/differential ... identifies 85 to 95% of cases ... day, followed by long
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
may precede the neurologic ... /Sepsis/Shock, Autoimmune ... Reversible course Differential ... (mean 58 mg/dL ... the underlying cause
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Management Summary Causes ... Hyperthyroidism - Autoimmune ... Dermatomyositis Clinical ... if levels > 8 mg
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis ... MALT Lymphoma • Lung
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary

WHAT?
 • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
disease of unknown cause ... CLINICAL: • Physical ... for giant cell arteritis ... diagnosed based on clinical ... normal and can help differentiate
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
(RA, Temporal arteritis ... Sarcoidosis) • Liver ... Cirrhosis, ETOH, autoimmune ... ovarian tumors, lung ... Gap #ProteinGap #differential