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diagnosis differential algorithm lfts obstetrics pregnancy biliary causes chemistry cholangitis cirrhosis comparison disease fatty hellp icp injury interpretation liverenzymes management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... ) Pathophysiology ... Diagnosis: Viral Hepatitis ... iMedEducation #AFLP ... Pregnancy #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... • Near normal ... Chronic viral hepatitis ... #differential #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... disease US — Normal ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... function may be abnormal ... Chronic viral hepatitis ... #injury #hepatitis ... diagnosis #algorithm #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Hepatic imaging: Normal ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis ... diagnosis #icp #HELLP #AFLP
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... obstruction • ALP ... or higher • Liver ... Diagnosis: • Viral hepatitis ... diagnosis #workup #hepatology
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