12 results
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... iMedEducation #AFLP ... #Fatty #Liver # ... Pregnancy #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... or AST > ALP): ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP ... Algorithm #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
phos/ULN ALP) ... specificity to elevated ALP ... GGT/5-NT: ↑ • ALP ... hepatitis: < 1 • Cirrhosis ... #differential #Hepatology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Syndrome and Acute Fatty ... (AFLP) Three syndromes ... plasma exchange 3) Fatty ... TTPHUS #HELLP #AFLP ... #obstetrics #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Algorithm Severe ALT ... • Pregnancy - AFLP ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
specificity to elevated ALP ... • AST/ALT > ALP ... GGT/5-NT: ↑ - ALP ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
hemorrhage Acute Fatty ... (AFLP) • Onset ... Hepatic imaging: Fatty ... Disease #Pregnancy #hepatology ... diagnosis #icp #HELLP #AFLP
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Hemolysis, Elevated Liver ... plasma exchange 2) Fatty ... liver of pregnancy ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary Cirrhosis ... Elevated ALP 2. ... Liver biopsy findings ... Primary #Biliary #Cirrhosis ... Diagnosis #Algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... /Liver failure ... obstruction • ALP ... or higher • Liver ... diagnosis #workup #hepatology