Maturation deficiency hematology diagnosis rash purpura lupus alopecia systemic syndrome causes hairloss differential anemia sle extravascular mas rheumatology granulomatosis

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Causes Intravascular ... thrombocytopenic purpura ... G6PD deficiency) ... #Causes #differential ... #diagnosis #hematology

Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and

GPA causes disease ... reticularis Differential ... • Goodpasture syndrome ... #rash #diagnosis ... #rheumatology

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... Differential ... disease • Prolidase deficiency ... #Systemic #Lupus ... #Rheumatology

Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of

rash) • Heart, ... [SLE], AOSD) • ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology

Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,

Diagnosis: • Systemic ... SLE, atherosclerotic ... , mucositis • Rash ... tract, and often causes ... #Diagnosis #Rheumatology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

tract, and often causes ... mucositis - Rash ... Diagnosis: Systemic ... systemic lupus ... #diagnosis #rheumatology

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