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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis
Iron Panel Interpretation

Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation,  ↓
Interpretation Iron deficiency ... Ferritin Iron deficiency ... Interpretation #deficiency ... #diagnosis #differential ... #hematology #laboratory
Diagnostic Criteria for Systemic Lupus Erythematosus - ACR and SLICC Criteria

#Diagnosis #Rheumatology #SLE #Lupus #Erythematosus #Criteria
Diagnostic Criteria ... Systemic Lupus Erythematosus ... - ACR and SLICC ... Criteria #Diagnosis ... #Rheumatology #
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... Signs #Symptoms #Rheumatology ... #Diagnosis
Hematopoietic Stem Cell Lineage

#Hematopoietic #StemCell #Lineage #hematology #diagnosis #maturation
StemCell #Lineage #hematology ... #diagnosis #maturation
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... Diseases: • GATA2 deficiency ... Inflammatory and ... Systemic lupus erythematosus ... #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
- Differential Diagnosis ... and non-hematologic ... Myelodysplasia Nutritional deficiency ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
SHARP - Lupus Diagnosis ... Antinuclear Antibody (ANA ... Pleuritis) H Hematologic ... systemic #lupus #erythematosus ... #rheumatology #
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Systemic lupus erythematosus ... Systemic lupus erythematosus ... Antinuclear #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
- Differential Diagnosis ... blood loss (Fe deficiency ... Non-infectious (malignancy, rheumatologic ... #Differential #Diagnosis ... causes #Platelets #hematology