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diagnosis hematology hemolytic algorithm oncology agglutinin classification common cvid disease extravascular hodgkins hypogammaglobulinemia immunodeficiency immunology intravascular lymphoma mds myelodysplasia myelodysplastic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... lymphoproliferative disorders ... #differential # ... #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
AIHA Primary Secondary ... Secondary Cold ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... Consider RBC membrane disorder ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... Diagnosis and Workup ... practices that could ... changes), high MCV anemia ... #Workup #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Diseases Nail Fold ... Iron deficiency anemia ... #dermatology #Differential ... Diagnosis #Algorithm #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... leakage of RBC's secondary ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #nonpalpable #dermatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... infection risk secondary ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... DDX: Rule Out Secondary ... Causes • Anemia ... blood count with differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... #oncology #management
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