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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... #venn #nephrology ... #nephritis #classification ... #types #rheumatology
Vasculitis - Break down based on vessel size 
Distribution of vessel involvement by large vessel vasculitis,
Vasculitis - Break ... can affect any type ... Anti-GBM = anti–glomerular ... #Diagnosis #Rheumatology ... Medium #Large #Classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... systemic lupus erythematosus ... #classification ... #rheumatology #
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Kidney Injury - Classification ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... tubular necrosis (causes ... #diagnosis #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... - Skin, glomeruli ... : - Kidneys: glomerular ... differential #diagnosis #rheumatology ... #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... Kikuchi disease • Type-I ... #Diagnosis #Rheumatology
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... infections are common causes ... for ANCA-related vasculitis ... cryoglobulinemias (types ... nephrotic #nephritic #nephrology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
affects the skin, neurologic ... • Kidneys: Non-glomerular ... ischemia • Skin: Erythematous ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... infections are common causes ... for ANCA-related vasculitis ... cryoglobulinemias (types ... initial #testing #nephrology