9 results
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... Like in this case ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... thigh bones -> chronic ... mineralization Symptoms ... - Pain (muscle/joint ... Phosphatase: • Other causes
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
or nerve root Symptoms ... : • Acute or chronic ... e.g., meniscal tears ... #Pain #MSK #rheumatology ... #approach #workup
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Arthritis Differential Diagnosis ... constitutional symptoms ... weeks) Can Be Caused ... #Differential #Diagnosis ... #MSK #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... -> AML: Blast crises ... bone pain, fever, joint ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
• Progressive symptoms ... Eosinophilia, asthma, chronic ... tract, and often causes ... Palpable purpura, joint ... #Rheumatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... Marrow Failure • Chronic ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Eosinophilia, asthma, chronic ... tract, and often causes ... vesicular eruption - Joints ... Presentation - Systemic Symptoms ... #rheumatology #
A quick infographic on various pearls about atopic dermatitis, a disease with an increasing burden on
Dermatitis (AD) is a chronic ... medications #treatment #diagnosis ... #causes #atopy ... /hyperactivity symptoms ... Pedersen MS, Benros