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diagnosis hematology chronic leukemia lymphocytic oncology cvid differential gap globulin hemeonc hemophagocytic hlh hypogammaglobulinemia immunodeficiency immunology lymphohistiocytosis protein proteingap treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... • Neutropenia, anemia ... kinase (BTK) Complications ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Overview: • Most common ... 5) Symptoms of anemia ... thrombocytopenia Complications ... uw_IMresidency #CLL ... hemeonc #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... noninfectious complications ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... symptoms can mimic common ... Low or absent NK cell ... Lymphohistiocytosis #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
myeloma • Plasma cell ... changes (POEMS syndrome ... Liver disease: Cirrhosis ... anemia • Other ... Comment on type
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