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Methadone.  Long half-life opioid originally developed in  1930s Germany.

#Pharmacology #Methadone #Methadose #Dolophine #Overview #Review
Methadone. ... #Pharmacology #Methadone ... #Methadose #Dolophine
Methadone - Pharmacology, Dosing and Interactions

Methadone is more of an Art than a Science, it’s a
Methadone - Pharmacology ... Interactions Methadone ... monitor the QTc #Methadone
Methadone Hospital Quick Start - Inpatient Initiation for Opioid Use Disorder and Withdrawal
Initial Dosing:
 - Patients
Methadone Hospital ... - Allergy to methadone ... give additional methadone ... #Methadone #Hospital
Methadone Drug-Drug Interactions
Meds that increase methadone metabolism/decrease methadone effect (INCREASED RISK FOR OPIOID WITHDRAWAL):
 • Phenytoin,
Methadone Drug-Drug ... that increase methadone ... metabolism/decrease methadone ... that decrease methadone ... Indinavir, Azoles #Methadone
Quick Guide: Methadone Starts in the Hospital
Day 1: max daily dose 40 mg methadone
First dose
• Check
Quick Guide: Methadone ... daily dose 40 mg methadone ... Administer 10-30mg methadone ... daily dose 50 mg methadone ... Treatment (SHOUT) #Methadone
Methadone in Hospice & Palliative Care
Appropriate Candidates:
 - Moderate to severe pain
 - Pain refractory to
Methadone in Hospice ... risk factors for methadone ... projected time to methadone ... cindyPharMPH #Methadone
CA-Bridge Buprenorphine Hospital Quick Start Algorithm - Management of acute opiate withdrawal 
 - Any prescriber
patient is stable on methadone ... or prefers methadone ... continuation of methadone
Torsades de Pointes 
•Precipitated by drugs that prolong the QT interval 
•Class IA antidysrhythmics (procainamide, quinidine)
Erythromycin •Methadone
Inpatient Management of Opioid Use Disorder: Methadone vs Buprenorphine - Comparison Table

Some patients may decline buprenorphine
Use Disorder: Methadone ... buprenorphine or methadone ... Treatment (SHOUT) #Methadone
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
as morphine and methadone ... Methadone is a long-acting ... , morphine, or methadone ... Methadone exhibits ... #Pharmacology #Methadone