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management hematology hemophagocytic hlh lymphohistiocytosis neurology antinxp2 antinxp2dm arteritis brain comatose crypto cryptococcal dermatology dermatomyositis disease giantcell igg4 macrophage mas
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... systemic sx + signs ... Treatment of GCA ... per day or 1 mg ... them, but urgent rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... Etoposide/VP16 (100 mg ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... SJIA], systemic lupus ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Related Disease Clinical ... with response to treatment ... Glucocorticoids (0.6 mg ... GC-dependency ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... : HLH signs and ... • Bicytopenia Treatment ... #hematology
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
Differential Diagnosis ... ascending reticular activating ... • Examine for signs ... in coma) • If ok ... caseyalbin #PhysicalExam
Neurosarcoidosis - Diagnosis and Treatment • 5 to 40% of sarcoidosis, Heterogeneous, often inaugural • Central
and Treatment ... neurosarcoidosis: Clinical ... Treatment ~ 2 ... Infliximab 3-5 mg ... #neurology #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... auricular papules Clinical ... positive patients Treatment ... Prednisone at 1 mg ... #management #rheumatology
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
Diagnosis? ... organism (soap bubble sign ... Standard treatment ... losses of K+ & Mg ... T2 #MRI #Brain #clinical
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