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oncology differential anemia aplastic chronic clinical cll dermatology disorders globulin history lymphocytic management mds monoclonal myelodysplasia myelodysplastic paraproteinemias pediatrics primarycare
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Hepatomegaly • Skin ... • Sezary syndrome ... #diagnosis #workup ... #oncology #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... ecchymoses, mucosal bleeding ... virus (EBV) • Leukemia ... Anemia #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... just beneath the skin ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... changes (POEMS syndrome ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
Monkeypox Skin Rash 30 yr F and her 6 yr daughter purchased 2 prairie dogs 10 days
Monkeypox Skin Rash ... dogs 10 days ago (pers ... Diagnosis? ... SkinRash #clinical #photo ... #dermatology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
and skin haemorrhage ... Marfan syndrome, ... #History #peds ... #pediatrics #diagnosis ... #hematology #primarycare
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