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diagnosis hematology algorithm differential macrocytic oncology aafp apl b12 bloodsmear causes clinical cobalamin deficiency elevatedmcv folate folicacid homocysteine leukemia management
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... blood smear showed ... hypogranular neutrophils ... rods in neutrophils ... #Smear #Microscopy
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 Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
> 10% Band neutrophils ... than segmented neutrophils ... Band neutrophils ... in German) • Neutrophils ... Shift) → Segmented Neutrophil
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Hypersegmented Neutrophils ... • Pernicious Anemia ... • Pernicious Anemia ... #Macrocytic #Anemia
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
proportion of the red blood ... leads to anemia ... blood cell lines ... ml (or absolute neutrophil ... neutropenia since neutrophils
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
of macrocytic anemia ... (RBC = red blood ... elevated, but anemia ... megaloblastic anemia ... #Macrocytic #Anemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... Leukemia): • Neutrophils ... Leukemia): • Neutrophils ... Age: 50-60 • Auer ... - infiltrates (anemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... (hypogranular neutrophils ... • Aplastic Anemia ... Megaloblastic Anemia ... blood smear •
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
autoantibodies (pernicious anemia ... Worsening macrocytic anemia ... wt loss • If anemia ... , PBS - anemia, ... hypersegmented neutrophils
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