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diagnosis anemia oncology agglutinin bandemia causes cbc classification cold extravascular hemolysis hodgkins intravascular lymphoma management neutrophil paraproteinemias pathophysiology wbc
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
uremic syndrome ... (HUS) • Other ... usually IgG) (e.g. lupus ... Extravascular #Causes #differential ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... to cold IgG • Lupus ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Cell population has ... on the left Myeloblast ... • Autoimmune diseases ... neutrophil #WBC #CBC #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... nodosum • Immune hemolytic ... number of sites of disease ... Hodgkin Lymphoma Treatment ... classification #hematology
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