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anemia differential hemolytic oncology rheumatology agglutinin algorithm causes chronic cold hemeonc hemophagocytic hepatitis hodgkins injury intravascular leukemia liver lymphocytic lymphohistiocytosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... , lymphoma, idiopathic ... usually IgM) (e.g. primary ... • Intrinsic RBC ... #hematology #anemia
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
assessment+++ Primary ... lymphoma, B-cell ... , intravascular ... solid cancers • Autoimmune ... #management #treatment
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... • Autoimmune: ... , HLH • Neoplasm ... lung CA, lymphoma ... #algorithm #hepatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... disorder or lymphoid ... Diagnosis: • hemolytic ... Blood smear - RBC ... #hematology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
platelets - WBC ... Treatment • Early ... #diagnosis #classification ... #hematology #oncology ... #management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... lymphoma (Richter ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
biliary cirrhosis ... Nephrogenic DI Hematologic ... • B cell lymphoma ... Adenocarcinoma Treatment ... #Diagnosis #Management
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