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diagnosis chronic cll common cvid differential gammopathies globulin immunodeficiency immunology lymphocytic mgus monoclonal multiplemyeloma protein proteingap variable workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... rendering the immune system ... ’s CLL Scoring system ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... Neutrophils • Immature/Myeloblasts ... lymphoid organs When Cancer ... Agranulocytosis • Hypogammaglobulinemia ... #Hematology #Oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Lymphoma or other cancers ... gastric and breast cancer ... hemolytic anemia) • Systemic ... DDX - Other causes ... #immunology #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Look for gamma gap ... plasmacytoma, POEMs syndrome ... macroglobulinemia, and autoimmune ... MGUS #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Cirrhosis, ETOH, autoimmune ... ovarian tumors, lung cancers ... gastric tumors • Hematology ... differential #diagnosis #hematology
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