4 results
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Look for gamma gap ... (total protein ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Lymphoma or other cancers ... hemolytic anemia) • Systemic ... DDX - Other causes ... • Burns • Protein-losing ... #immunology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Gap (Total Protein ... Causes of Monoclonal ... gastric tumors • Hematology ... Comment on type ... differential #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... Neutrophils • Immature/Myeloblasts ... lymphoid organs When Cancer ... Agranulocytosis • Hypogammaglobulinemia ... #Hematology #Oncology