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diagnosis hemolytic monoclonal algorithm causes disease extravascular hemolysis intravascular paraproteinemias testing workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... ), CLL, Myeloma ... #hemolytic #anemia ... #hematology #diagnosis
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... @AnnKumfer #MultipleMyeloma ... #MGUS #diagnosis ... #hematology #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... agglutinins disease ... ARUPLabs #Hemolytic #Anemia ... Algorithm #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... agglutin disease ... Hemoglobinopathies (e.g. sickle cell ... #diagnosis #hematology ... #anemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
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