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Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
(GPA) Skin involvement ... GPA causes disease ... • Pauci-immune vasculitis ... vasculitis (inflamed ... GPA #dermatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... - GPA, EGPA, microscopic ... • IgA vasculitis ... • Vasculitis ... vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
• Microscopic Polyangiitis ... Vasculitis - Skin ... mucositis - Rash ... #rheumatology # ... classification
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... : Erythematous nodules ... , mucositis • Rash ... MPO > PR3 60/ GPA ... tract, and often causes
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
gangrenosum • Cutaneous ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... #Hematology #Monoclonal ... #Differential #