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diagnosis management algorithm neurology oncology abnormal agglutinin alkaline alp anemia cancer cold common cryofibrinogenemia cvid enzymes gbs guillain hemolytic hyophosphatasia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... Diagnosis Secondary ... Myelodysplastic syndrome ... MF) • Chronic myeloid ... #hematology #secondary
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... CML (Chronic Myeloid ... • Neutrophils (myeloid ... AML (Acute Myeloid ... #Leukemia #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... significance (MGUS), CLL, Myeloma ... hemolytic #anemia #hematology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
severe clinical ... due to chronic disease ... overload) Other Symptoms ... #Nutrition #Differential ... #Diagnosis #Pathophysiology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... directed towards the myelin ... than one after symptom ... the underlying pathophysiology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... to 8 years Clinical ... DDX - Other causes ... infections (Epstein-Barr ... hypogammaglobulinemia #immunology #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... Diagnosis: • + Clinical ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
symptoms/signs ... urgent referral to secondary ... presence of metabolic syndrome ... Abnormal #Algorithm #Hepatology ... Liver #Enzymes #Differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... , or all three myeloid ... DDX: Rule Out Secondary ... Myeloproliferative Disease ... #diagnosis #hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
pain • loss of secondary ... Malnutrition • Wilson's disease ... mineralization Symptoms ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
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