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diagnosis oncology agglutinin disease gammopathies gammopathy gap globulin hemolytic multiplemyeloma paraproteinemias proteingap significance undetermined
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
protein level <3 ... No evidence of anemia ... protein level ( ... insufficiency, Anemia ... protein level <
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Protein/M Component ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... younger pts) Differential ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... gamma gap (total protein ... #Gammopathies #MGUS ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... • Multiple myeloma ... Smoldering multiple myeloma ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
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