179 results
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... criteria for 1) hematologic ... conditions - multiple myeloma ... peripheral blood myeloid ... cells NEJM Review
Hypersegmented neutrophil in a case of acute myeloid leukemia.

Dysplastic neutrophils are typically hypolobated but can be
neutrophil in a case ... of acute myeloid ... AML #Clinical #Hematology ... #Pathology #Smear
Dysplasia in Myelodysplastic Syndrome 
 - 
Dysgranulopoiesis 
 - Dyserythropoiesis 
 - Dysmegakaryopoiesis 

#Dysplasias #MDS #Myelodysplastic
Myelodysplastic Syndrome ... Myelodysplastic #Syndrome ... #Pathology #Hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... Myelodysplastic syndrome ... MF) • Chronic myeloid ... Differential #Diagnosis #Causes ... #hematology #secondary
Priapism 

Secondary Causes:
Medications- intracavernosal injections, anticoagulants, PDE5 inhibitors, alpha blockers, methylphenidate, cocaine
Any hyperviscosity syndrome (SCD, leukemia,
Secondary Causes ... hyperviscosity syndrome ... SCD, leukemia, myeloma ... or are zebras (…amyloid
Causes of Erythema Nodosum - Mnemonic

NO cause found in 60% of cases
Drugs (antibiotics e.g., sulfonamides, amoxicillin)
Oral
Causes of Erythema ... Mnemonic NO cause ... Sarcoidosis or Lofgren's syndrome ... Nodosum #Mnemonic #Causes ... Differential #Diagnosis #Dermatology
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Myelofibrosis • Chronic Myeloid ... Differential #Diagnosis #causes ... #Platelets #hematology
A non-subtle example of true Sezary syndrome.  Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... Cells #Clinical #Pathology ... Smear #Microscopy #Hematology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
lymphoma, melanoma, myeloma ... Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... Differential #Diagnosis #causes ... #hepatology
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
other forms of myeloma ... Clinical #Smear #Hematology ... #Pathology