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diagnosis abnormal agglutinin atlas autoinflammatory beaus cll differential diseases e1 fingernails hemolytic leukemia lymphocytic mees monoclonal myelodysplasia myelodysplastic nail paraproteinemias
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... thromboembolic disease ... Abnormalities: macrocytic anemia ... cells NEJM Review
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... Viral Infection Clinical ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
, or all three myeloid ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #diagnosis #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Physical Exam/Signs ... cells can indicate disease ... • Neutropenia, anemia ... #hematology
Nail Pathologies - Findings in or Near Nails Paronychia A superficial infection of the proximal and lateral
Chronic infections ... include diabetes, anemia ... illness, trauma, and cold ... #Abnormal #Pathology ... #Signs #PhysicalExam
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