37 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myositis and Myopathies ... #ESR #CK #Differential ... #Inflammatory ... #myopathies #Dermatomyositis ... Fibromyalgia #Hypothyroid
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... Endocrinopathies: Hypothyroid ... • Metabolic myopathies ... certain drug-induced myopathies ... #Weakness #Differential
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory ... Myopathies - ... Inclusion Body Myositis ... #Myopathies #Idiopathic ... #Rheumatology #Differential
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... Inclusion Body Myositis ... , +Anti-dsDNA, Myositis ... #Myopathies #myopathy ... #differential #
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Myopathies (IIM's ... myopathies (IIM's ... • Overlap Myositis ... Inclusion body myositis ... #Myopathies #IIMs
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Inflammatory Myopathies ... Necrotizing Autoimmune Myositis ... Inclusion Body Myositis ... BrighamChiefs #Inflammatory ... #Myopathies #differential
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
That May Mimic Inflammatory ... Myopathy • Central ... • Metabolic myopathies ... Mitochondrial myopathy ... mimics #diagnosis #differential
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... , hypothyroid-induced ... inclusion body myositis ... myopathies such ... : Inflammatory statin
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Metabolic Myopathies ... toxoplasmosis - Inflammatory ... Inclusion body myositis ... #Elevated #CK #differential
Dysphagia - Differential Diagnosis Algorithm

Oropharyngeal Dysphagia 
Esophageal Dysphagia 
 • Upper 2/3 (striated muscle): stroke, NMJ
Dysphagia - Differential ... Entire length: RA. inflammatory ... myopathies Matthew ... #Dysphagia #Differential