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differential hematology clinical derm dermatomyositis nejm oncology photo vasculitis algorithm antimda5 antimda5dm antinxp2 antinxp2dm blastomycosis classification colitis disorders eosinophilia gangrenosum
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
incidentally during medical ... organ-specific signs ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Disseminated Cutaneous Blastomycosis- A fungal culture of skin tissue was negative; however, a skin biopsy showed
fungal culture of skin ... negative; however, a skin ... staining confirmed a diagnosis ... #clinical #photo ... #derm #NEJM #cutaneous
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous ... chest (in a V-sign ... ulcerations • Skin ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... purpura: Strong sign ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... aphthous ulcers, cutaneous ... purpura: strong sign ... of cutaneous leukocytoclastic ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... gangrenosum • Cutaneous ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... violaceous, nontender cutaneous ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Pyoderma Gangrenosum in Ulcerative Colitis- ...left chest (Panel A) and leg (Panel B). The physical examination
A diagnosis of pyoderma ... second most common dermatologic ... #clinical #photo ... #NEJM #pyoderma ... ulcerative #colitis #derm
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
in the neck Cutaneous ... chest (in a V-sign ... shoulders (in a shawl sign ... #management #rheumatology ... #dermatology
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