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diagnosis rheumatology management differential gammopathies mgus monoclonal multiplemyeloma myelitis neurology oncology sapho sjogrens transverse vasculitis
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
levels >1g/L • Negative ... cryoglobulins • Negative ... causes of secondary ... Antiphospholipid syndrome ... #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
cord compression (MRI ... change on spinal MRI ... Gadolinium-enhanced MRI ... tested and if negative ... out • Brain MRI
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
focal lesions on MRI ... Causes of false- ... negative SPEP: ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... affected areas and if negative ... - MRI: inflammation ... #Rheumatology # ... diagnosis #management #Dermatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... neuropathy, transverse myelitis ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Symptomatic: artificial tears
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Conjunctivitis, mucositis ... oligoclonal bands • MRI ... tract, and often causes ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
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