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diagnosis rheumatology management differential cryofibrinogenemia gammopathies mgus monoclonal multiplemyeloma myelitis neurology oncology sapho sjogrens transverse vasculitis
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
cord compression (MRI ... change on spinal MRI ... tested and if negative ... • Infectious causes ... out • Brain MRI
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
focal lesions on MRI ... Causes of false- ... negative SPEP: ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... affected areas and if negative ... - MRI: inflammation ... #Rheumatology # ... diagnosis #management #Dermatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
levels >1g/L • Negative ... cryoglobulins • Negative ... causes of secondary ... Antiphospholipid syndrome ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... neuropathy, transverse myelitis ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Symptomatic: artificial tears
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Conjunctivitis, mucositis ... oligoclonal bands • MRI ... tract, and often causes ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
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