31 results
Infective endocarditis - etiology and sources of infection. 
 • Native and prosthetic 
valve endocarditis
 •
Infective endocarditis ... and sources of infection ... • Soft tissue infections ... Sources #Causes ... #Differential #Microbiology
Endocarditis Algorithm - Infective vs Noninfective Causes
Noninfective:
 • Malignancy
 • Autoimmune disease
 • Systemic infection
Native Valve
Endocarditis Algorithm ... Noninfective Causes ... disease • Systemic infection ... amzn.to/2LmUODZ #Endocarditis ... #Noninfective #Causes
Aminoglycosides  - Antibiotics Class Overview

Gentamicin, Tobramycin, Amikacin, Streptomycin -30S inhibitor (all IV)
Spectrum: Extremely efficacious vs.
. aerobic Gram negatives ... infections especially ... urinary tract infections ... effect (mainly in endocarditis ... #Pharmacology #Antibiotics
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
and bacterial infections ... hours • Viral infections ... • Rickettsiae infections ... Pyogenic/focal infection ... endocarditis Non-Infectious
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... infective endocarditis ... #culture #negative ... #Endocarditis # ... InfectiousDiseases #Microbiology
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... • Infection with ... special media) • Infection ... history of prior infections ... #Infective #Endocarditis
Anaplasma Infection - Anaplasma phagocytophilum
Pathophysiology: 
 • Obligate, intracellular bacteria
 • Transmitted via blacklegged tick —
Anaplasma Infection ... ), cough (30% cases ... ) Laboratory findings ... #Anaplasma #Infection ... #diagnosis #microbiology
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
serology: Serial negative ... Frequent false-negative ... in up to 30% of cases ... large infarct - Infectious ... #comparison #infective
Daptomycin  - Antibiotics Class Overview

Mechanism: Lipopeptide antibiotic – forms transmembrane channels and depolarizes cells.
No gram negative ... skin/soft tissue infections ... MRSA bacteremia/endocarditis ... cidal nature) #Pharmacology
Disseminated Gonococcal Infection - Diagnosis and Management Summary

Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
Disseminated Gonococcal Infection ... spread of the Gram-negative ... symptomatic genital infection ... Disseminated #Gonococcal #Infection ... Diagnosis #Management #Microbiology