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monoclonal differential hemolytic agglutinin aiha aplastic autoimmune cell cold disease gammopathies gammopathy management multiplemyeloma paraproteinemias plasmacytoma significance solitary undetermined workup
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... - Differential Diagnosis ... Table Warm AIHA ... AIHA (7-8%) DAT-negative ... #Table #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... No evidence of anemia ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... Causes of false- negative ... #Gammopathies #MGUS ... #diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MGCS • MGRS ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... bone marrow + pancytopenia ... • Peripheral Pancytopenia ... #oncology #hematology ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... for anti-C3d and negative ... significance (MGUS ... #hematology #diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... marrow biopsy negative ... • No CRAB - no anemia ... #Plasmacytoma #Oncology ... #Hematology
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