20 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar rash ... versus DIL • Laboratory ... pANCA anti-MPO - Negative ... Erythematosus #Diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint Pain ... Rash • Human ... lesions • Discoid lupus ... #rashes #differential ... #diagnosis #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... calcium-b) • Laboratory ... Workup: - ANA ... pANCA anti-MPO - Negative ... #diagnosis #management
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
Inflammatory joint pain ... fingers, or pain ... everywhere) 2) A rash ... the face (many differential ... #diagnosis #sle
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... fever) and laboratory ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Arthritis: • Joint pain
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
69% - Malar rash ... Auto-Antibodies: - ANA ... Diagnosis and Lupus ... Lupusreference #SLE ... #rheumatology
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... sulfa-drug - Skin pain ... #Dermatology #Rash ... Targetoid #Algorithm #Differential ... #Ddxof
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... erythematosus (SLE ... (SLE), Systemic ... #patterns #rheumatology ... #diagnosis #differential
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
muscle weakness, rash ... • +ANA, +Anti-Smith ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential ... Diagnosis Algorithm ... lesions • Severe pain ... Autoimmune Vasculitis (lupus ... for hepatitis B and