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Non-infective endocarditis Characteristics and Pathophysiology

By Dr. Sara Dong @swinndong via #IDFellowCase

#ID  #Infectious Diseases  #Infections
#Differential
Non-infective endocarditis ... Characteristics and Pathophysiology ... #Infections #Differential ... #CNIE #Endocarditis ... #Cardiac #Pathophysiology
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
blood culture negative ... infective endocarditis ... #Causes #differential ... #Endocarditis # ... InfectiousDiseases
Microorganisms Responsible for Infective Endocarditis

Native valves:
 - Streptococcus viridans 
 - Enterococci 
 - Other streptococci
for Infective Endocarditis ... ) - Culture negative ... #Infective #Endocarditis ... Pathogens #Diagnosis #Differential ... #InfectiousDiseases
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... #Infective #Endocarditis ... #diagnosis #differential ... #workup #infectiousdiseases
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Cryoglobulinemia, Endocarditis ... Pauci-immune mediated (Negative ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... - Autoimmune Rheumatologic ... • Bacterial endocarditis ... aureus • Gram-negative ... #Joint #pain #Differential
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... likelihood of negative ... #Bandemia #differential ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
and Differential ... aureus, Coagulase-negative ... staphylococci Culture Negative ... #Differential # ... Diagnosis #cardiology #infectiousdiseases
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... Needle-shaped, negatively ... #CPPD #Gout #Comparison ... #rheumatology #
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
pulmonary symptoms • Rheumatologic ... Aspergillosis Pathophysiology ... arthritis, and endocarditis ... ) #Mycoses #InfectiousDiseases