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liver algorithm causes lfts obstetrics pregnancy chemistry cholangitis disease fatty gradient hellp hypertension icp injury liverenzymes obgyn pathophysiology pbc portal
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Production: • Albumin ... : < 1 • Cirrhosis ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Pregnancy - AFLP ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... Others #LFTs #Hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Serum Ascites Albumin ... Diagnosis High ... - Alcoholic hepatitis ... Tuberculosis - Biliary ... Diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... develops (DIC, ascites ... , jaundice, hypoglycemia ... iMedEducation #AFLP ... Liver #Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... disease - If ALP ... both are normal, ALP ... : < 1 • Cirrhosis ... #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Diagnosis Portal ... INR, bilirubin, albumin ... /acute hepatitis ... pregnancy • Primary biliary ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
hyperpigmentation • Jaundice ... obstruction • ALP ... bile ducts Differential ... Viral hepatitis, ... #workup #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Pruritus, Mild jaundice ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology ... #comparison #differential ... #HELLP #AFLP
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