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diagnosis differential management oncology aplastic causes cell cvid erythematosus gap globulin hypogammaglobulinemia immunodeficiency immunology lupus macrocytic macrocytosis plasmacytoma protein proteingap
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... Myelodysplastic Syndromes ... #Macrocytosis #elevatedMCV ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
: - Hepatitis ... (MDS) (normal or ... ) Labs: • Peripheral ... Treatment: ... #oncology #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... diseases and hepatitis ... autoimmune hemolytic anemia ... levels are within normal ... hypogammaglobulinemia #immunology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Noninfectious hepatitis ... Cytopenias • Cardiac valve ... , Serositis Labs ... Kidney disease common ... Erythematosus #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Sarcoidosis) • Liver ... gastric tumors • Hematology ... Comment on type ... differential #diagnosis #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
- GI tract, liver ... SPB - commonly ... • No CRAB - no anemia ... Bone marrow Treatment ... Diagnosis #Workup #Hematology
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