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diagnosis differential activation acute aih aplastic autoimmune cvid gap globulin hiv hypogammaglobulinemia immunodeficiency immunology injury lupus macrophage mas oncology polychondritis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Noninfectious hepatitis ... Cytopenias • Cardiac valve ... , Serositis Labs ... common • Antihistone ... #Diagnosis #Rheumatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... from subclinical disease ... Other Etiology of Hepatitis ... #Autoimmune #Hepatitis ... #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... - If both are normal ... Chronic viral hepatitis ... #injury #hepatitis ... #hepatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... and hepatitis ... autoimmune hemolytic anemia ... levels are within normal ... hypogammaglobulinemia #immunology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
: - Hepatitis ... ) Labs: • Peripheral ... Treatment: ... #oncology #hematology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• HLH Labs: ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Ocular examination Labs ... vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... #Rheumatology # ... Diagnosis #Management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
HBV, EBV, VZV, hepatitis ... ETOH, autoimmune hepatitis ... PBC, PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
infection - Most common ... manifestations Labs ... enzymes ↑ • Mild anemia ... infection • Viral hepatitis ... ART to slow HIV disease
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Females slightly > Males ... Anti-Matrilin-1 Ab ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
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