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diagnosis management differential activation acute aplastic classification cvid globulin hypogammaglobulinemia immunodeficiency immunology lupus macrophage mas nonpalpable oncology palpable protein proteingap
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Noninfectious hepatitis ... Cytopenias • Cardiac valve ... , Serositis Labs ... common • Antihistone ... #Diagnosis #Rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... deficiency • Liver ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
hepatitis C) • ... ETOH, autoimmune hepatitis ... PBC, PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
: - Hepatitis ... (MDS) (normal or ... ) Labs: • Peripheral ... Treatment: ... #oncology #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... and hepatitis ... levels are within normal ... , HIV) • Glucocorticoid ... hypogammaglobulinemia #immunology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
[SLE], AOSD) • ... • HLH Labs: ... with leukopenia, anemia ... Diagnosis #Management #Hematology ... #Rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
infection - Most common ... manifestations Labs ... • New onset SLE ... infection • Viral hepatitis ... disease progression
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Ocular examination Labs ... vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... #Rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Drug Associated (Commonly ... retinopathy Lab ... vasculitis, and SLE ... Cryoglobulins • HIV ... differential #diagnosis #rheumatology
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