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management differential activation acute aplastic chemistry common cvid gap globulin hypogammaglobulinemia immunodeficiency immunology injury interpretation lfts lupus mas oncology protein
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... - If both are normal ... Chronic viral hepatitis ... #injury #hepatitis ... #algorithm #hepatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• HLH Labs: ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Noninfectious hepatitis ... Cytopenias • Cardiac valve ... lymphopenia, low PLT • Anemia ... , Serositis Labs ... #Diagnosis #Rheumatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... Check Acute viral hepatitis ... Check Acute viral hepatitis ... Chronic viral hepatitis ... #differential #Hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
: - Hepatitis ... ) Labs: • Peripheral ... Treatment: ... #oncology #hematology ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... and hepatitis ... levels are within normal ... , HIV) • Glucocorticoid ... hypogammaglobulinemia #immunology #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
manifestations Labs ... enzymes ↑ • Mild anemia ... infection • Viral hepatitis ... disease progression ... #HIV #diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
hepatitis C) • ... ETOH, autoimmune hepatitis ... PBC, PSC, Viral hepatitis ... gastric tumors • Hematology ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Ocular examination Labs ... vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... Nephrogenic DI Hematologic ... #Rheumatology #
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