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gammopathy management monoclonal differential hodgkins lymphoma rouleaux significance smear algorithm anemia aplastic biopsy blood causes cell classification coagulation comparison cryofibrinogenemia
Rouleaux formation is common in IgM gammopathy and may be particularly striking Genevieve Crane, MD, PhD@evemariecrane #Rouleaux #formation
Rouleaux formation ... #Rouleaux #formation ... IgM #gammopathy #MGUS ... #Clinical #Pathology ... #Hematology #Smear
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS ... - Differential Diagnosis ... #Differential #Diagnosis ... #hematology #oncology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
, low-risk MGUS ... protein <1.5 gm/dL, normal ... whom there are no clinical ... Biopsy #algorithm #diagnosis ... #management #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... sub-types based on the hematologic ... : • Abnormal FLC ... #Significance #hematology ... #diagnosis #oncology
Autoagglutination should also be distinguished from “Rouleaux formation” wherein normal blood tends to form stacks on
from “Rouleaux formation ... ” wherein normal ... dilution with normal ... #Clinical #Pathology ... #Hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MGCS • MGRS ... Cryoglobulinemic, Hypo/normo-complementemic ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Autoimmune diseases • Clinical ... Differential Diagnosis ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
fatigue, bone pain, abnormal ... ) • Rouleaux formations ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology ... #Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... significant fibrin clot formation ... - APTT < 1.5 x normal ... #Coagulation #diagnosis ... treatment #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... syndrome (MDS) (normal ... megakaryocytes and a normal ... Aplastic #Anemia #oncology ... #hematology #diagnosis
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