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diagnosis algorithm differential liver primary abnormal transaminitis causes chemistry cholangitis comparison elevated enzymes hepatitis hepatopulmonary hps injury interpretation liverenzymes liverfunctiontests
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Disease: Primary Biliary ... Cirrhosis vs Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
AST): • US - Normal ... Ducts - PBC ... - CBD stone, Biliary ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Cirrhosis - Pathophysiology ... relative with PBC ... Cholestasis #PBC ... #Cirrhosis #Pathophysiology ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... Pathophysiology ... • ALT & AST normal ... #Cirrhosis #PBC ... diagnosis #workup #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
disease US — Normal ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... • Others #LFTs ... #Hepatology #LiverEnzymes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... - If both are normal ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... - If both are normal ... hepatitis: < 1 • Cirrhosis ... #differential #Hepatology ... transaminitis #LFTs
Primary Biliary Cirrhosis - Management A. Initiate therapy - Initiate 1st line therapy with UDCA (13-15
Primary Biliary ... Cirrhosis - Management ... 1.5x ULN and/or abnormal ... survey disease #PBC ... #Treatment #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... include extrahepatic biliary ... body mass index; FBC ... #LFTs #Abnormal ... #Algorithm #Hepatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
abnormalities PATHOPHYSIOLOGY ... overperfusion + decreased RBC ... • Stigmata of cirrhosis ... Liver disease &/or portal ... #diagnosis #hepatology
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