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hepatology differential algorithm hepatitis lfts abnormal biliary chemistry cholangitis cirrhosis congenital disease enzymes gastroenterology hellp hyperbilirubinemia icp inherited injury interpretation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Hepatic imaging: Normal ... necrosis HELLP Syndrome ... of Pregnancy (AFLP ... obstetrics #hepatitis #comparison ... #differential #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... • Near normal ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... vein: Budd-chiari syndrome ... - If both are normal ... • Gilbert's syndrome ... #differential #diagnosis
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
hyperbilirubinemia syndrome ... of about 30% of normal ... of hemolysis or liver ... examination; nonspecific symptoms ... #hepatology #diagnosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
PBC Signs and Symptoms ... • ALT & AST normal ... slightly elevated • Bilirubin ... - Normal early ... obstruction • ALP
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... suspicious clinical symptoms ... presence of metabolic syndrome ... ALP, alkaline phosphatase ... #Algorithm #Hepatology
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