11 results
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Tests - Differential ... or AST > ALP): ... Wilsons, Pregnancy - AFLP ... Burak @kwburak #LFTs ... #hepatology #LiverFunctionTests
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... • Near normal ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Pregnancy - AFLP ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Diagnosis Algorithm ... Vascular Causes ... GGT/5-NT: ↑ - ALP ... function may be abnormal ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... Hepatitis, Preeclampsia ... iMedEducation #AFLP
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
of Pregnancy (AFLP ... #obstetrics #hepatitis ... #comparison #differential ... #diagnosis #icp ... #HELLP #AFLP
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
ALP, alkaline phosphatase ... mellitus; USS, ultrasound ... #LFTs #Abnormal ... #Algorithm #Hepatology ... Liver #Enzymes #Differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... obstruction • ALP ... bile ducts Differential ... Viral hepatitis, ... #workup #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Castleman disease • AL ... HBV, EBV, VZV, hepatitis ... chain assay • An abnormal ... Gap #ProteinGap #differential ... #diagnosis #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... fluid (CSF) is abnormal ... tract, and often causes ... , Elevated AST ALT