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diagnosis differential neurology management rheumatology aids classification cns infectiousdiseases inflammatory manifestations myelitis neurological opportunistic reconstitution syndrome tb transverse tuberculosis vasculitides
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Immune Reconstitution ... of treatment of HIV ... • 10-20% of HIV-infected ... increase in CD4+ cells ... weeks for most OI
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
• IRIS might ... less than 200 cells ... required until immune ... more than 200 cells ... patients with IRIS
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
to exclude are infections ... Presentation - Systemic Symptoms ... Arthralgias • Eye ... Eye -> retinopathy ... Cryoglobulins • HIV
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
Inflammatory Syndrome (IRIS ... ): • In HIV+, usually ... Meningitis • Include: vasculitis ... • Caused by immune ... and not direct infection
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
to exclude are infections ... Presentation: Systemic Symptoms ... Arthralgias • Eye ... Multinucleated giant cells ... • Progressive symptoms
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
activation of an immune ... mediated disease • Immune ... Bilateral signs and/or symptoms ... simplex virus, HIV ... - Sjogren - Vasculitis
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