13 results
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Findings: • ↑AST/ALT ... ) Differential Diagnosis ... Maternal Support - Critical ... Pregnancy #hepatology ... obstetrics #obgyn #diagnosis
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Anti-LKM & Anti-ALC ... Hepatitis (eg Viral) Management ... immunosuppressive tx: - ALT ... > 10x ULN - ALT ... #Management #Hepatology
The Neurological Evaluation of a Comatose Patient

Definition:
 • Coma: a state of unresponsiveness; the absence of
Differential Diagnosis ... ascending reticular activating ... stimulation to all ... for presence of clonus ... #PhysicalExam #neurology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... synthesized in: liver ... adult population: also ... respiratory failure • Neurologic ... Hyophosphatasia #hepatology
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Lateral Sclerosis (ALS ... Increased Jaw Jerk reflex ... , Clonus, Spasticity ... Lateral #Sclerosis #neurology ... #diagnosis #management
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Hepatitis B - Diagnosis ... and Management ... inflammation (decr ALT ... #Management #Treatment ... #Hepatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
complex → plt activation ... : • Clinical Suspicion ... D/c all heparin ... non-heparin A/C if clinical ... #Hematology #HemeOnc
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... the disease is also ... #management #treatment ... #hematology
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
and occurs at all ... disease management ... trial of UDCA for all ... remain subject to clinical ... #Hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... Fever is the main clinical ... tests ↑ AST ↑ ALT ... #Syndrome #Diagnosis ... #Management #Hematology